Delete Music Clip Or Another Sound In. To delete a music clip or another sound in PowerPoint do the following. You can add audio such as music narration or sound bites to your PowerPoint presentation.

It may take some time depending on the video length and your bandwidth speed. Click on the Export button. Here is the easiest way to remove sound clip from YouTube Video.
So if your question is can you remove mute the original audio and replace it with music and then save that as a new movie the answer is yes.
Now the audio will appear in a separate audio track. In the Media Library if you right click the video you can Extract Audio. Just select your MP4 file max 500MB and click the upload button. To get rid of the video you can do one of three things.